Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus
We have recently shown that physiological delay can induce a novel form of sustained temporal chaos we call delay-induced uncertainty (DIU) (Karamched et al. (Chaos, 2021, 31, 023142)). This paper assesses the impact of DIU on the ability of the glucose-insulin system to maintain homeostasis when re...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.936101/full |
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| author | Bhargav R. Karamched Bhargav R. Karamched Bhargav R. Karamched George Hripcsak Rudolph L. Leibel Rudolph L. Leibel David Albers David Albers William Ott |
| author_facet | Bhargav R. Karamched Bhargav R. Karamched Bhargav R. Karamched George Hripcsak Rudolph L. Leibel Rudolph L. Leibel David Albers David Albers William Ott |
| author_sort | Bhargav R. Karamched |
| collection | DOAJ |
| description | We have recently shown that physiological delay can induce a novel form of sustained temporal chaos we call delay-induced uncertainty (DIU) (Karamched et al. (Chaos, 2021, 31, 023142)). This paper assesses the impact of DIU on the ability of the glucose-insulin system to maintain homeostasis when responding to the ingestion of meals. We address two questions. First, what is the nature of the DIU phenotype? That is, what physiological macrostates (as encoded by physiological parameters) allow for DIU onset? Second, how does DIU impact health? We find that the DIU phenotype is abundant in the space of intrinsic parameters for the Ultradian glucose-insulin model—a model that has been successfully used to predict glucose-insulin dynamics in humans. Configurations of intrinsic parameters that correspond to high characteristic glucose levels facilitate DIU onset. We argue that DIU is pathogenic for obesity and type-2 diabetes mellitus by linking the statistical profile of DIU to the glucostatic theory of hunger. |
| first_indexed | 2024-04-14T05:44:45Z |
| format | Article |
| id | doaj.art-47c71ef13d7441b3b0831784fd6c6ae8 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T05:44:45Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-47c71ef13d7441b3b0831784fd6c6ae82022-12-22T02:09:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-09-011310.3389/fphys.2022.936101936101Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitusBhargav R. Karamched0Bhargav R. Karamched1Bhargav R. Karamched2George Hripcsak3Rudolph L. Leibel4Rudolph L. Leibel5David Albers6David Albers7William Ott8Department of Mathematics, Florida State University, Tallahassee, FL, United StatesInstitute of Molecular Biophysics, Florida State University, Tallahassee, FL, United StatesProgram in Neuroscience, Florida State University, Tallahassee, FL, United StatesDepartment of Biomedical Informatics, Columbia University, New York, NY, United StatesDivision of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, NY, NY, United StatesNaomi Berrie Diabetes Center, Columbia University Irving Medical Center, NY, NY, United StatesDepartment of Biomedical Informatics, Columbia University, New York, NY, United StatesSection of Informatics and Data Science, Department of Pediatrics, Department of Biomedical Engineering, and Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, United StatesDepartment of Mathematics, University of Houston, Houston, TX, United StatesWe have recently shown that physiological delay can induce a novel form of sustained temporal chaos we call delay-induced uncertainty (DIU) (Karamched et al. (Chaos, 2021, 31, 023142)). This paper assesses the impact of DIU on the ability of the glucose-insulin system to maintain homeostasis when responding to the ingestion of meals. We address two questions. First, what is the nature of the DIU phenotype? That is, what physiological macrostates (as encoded by physiological parameters) allow for DIU onset? Second, how does DIU impact health? We find that the DIU phenotype is abundant in the space of intrinsic parameters for the Ultradian glucose-insulin model—a model that has been successfully used to predict glucose-insulin dynamics in humans. Configurations of intrinsic parameters that correspond to high characteristic glucose levels facilitate DIU onset. We argue that DIU is pathogenic for obesity and type-2 diabetes mellitus by linking the statistical profile of DIU to the glucostatic theory of hunger.https://www.frontiersin.org/articles/10.3389/fphys.2022.936101/fulldelay-induced uncertaintyglucostatic hypothesislyapunov exponentobesitysheartheory of rank-one maps |
| spellingShingle | Bhargav R. Karamched Bhargav R. Karamched Bhargav R. Karamched George Hripcsak Rudolph L. Leibel Rudolph L. Leibel David Albers David Albers William Ott Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus Frontiers in Physiology delay-induced uncertainty glucostatic hypothesis lyapunov exponent obesity shear theory of rank-one maps |
| title | Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus |
| title_full | Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus |
| title_fullStr | Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus |
| title_full_unstemmed | Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus |
| title_short | Delay-induced uncertainty in the glucose-insulin system: Pathogenicity for obesity and type-2 diabetes mellitus |
| title_sort | delay induced uncertainty in the glucose insulin system pathogenicity for obesity and type 2 diabetes mellitus |
| topic | delay-induced uncertainty glucostatic hypothesis lyapunov exponent obesity shear theory of rank-one maps |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.936101/full |
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