Characterization of atypical T cells generated during ex vivo expansion process for T cell-based adoptive immunotherapy

Characterization of atypical T cells generated during ex vivo expansion process for T cell-based adoptive immunotherapy

Engineered T cell-based adoptive immunotherapies met promising success for the treatment of hematological malignancies. Nevertheless, major hurdles remain to be overcome regarding the management of relapses and the translation to solid tumor settings. Properties of T cell-based final product should...

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Bibliographic Details
Main Authors: Patricia Mercier-Letondal, Abhishek Kumar, Chrystel Marton, Francis Bonnefoy, Maxime Fredon, Laura Boullerot, Barbara Dehecq, Olivier Adotévi, Yann Godet, Jeanne Galaine
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
T cell-based adoptive cell immunotherapy
transgenic TCR T cells
CD8 and CD4 expression
MHC restriction
ex vivo T cell culture process
T cell function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1202017/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1202017/full

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