Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs

Mutations in the H7 HA and PB1 genes of avian influenza a viruses increase viral pathogenicity and contact transmission in guinea pigs

ABSTRACTAvian influenza A viruses (AIV) of the H7 subtype continue to evolve posing a pandemic threat. However, molecular markers of H7N7 AIV pathogenicity and transmission in mammals remain poorly understood. In this study, we performed a systematic in vitro and in vivo analysis by comparing an H7N...

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Bibliographic Details
Main Authors: Carola Dreier, Patricia Resa-Infante, Swantje Thiele, Stephanie Stanelle-Bertram, Kerstin Walendy-Gnirß, Thomas Speiseder, Annette Preuss, Zacharias Müller, Hans-Dieter Klenk, Jürgen Stech, Gülsah Gabriel
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
H7 avian influenza A viruses
HA and PB1 gene mutations
pathogenicity
transmission
guinea pigs
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1663131

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https://www.tandfonline.com/doi/10.1080/22221751.2019.1663131

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