Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle. We compared the levels of prodynorphin (PDYN) and proenkephalin (PENK) mRNAs (by qRT-PCR), and dynorphins and enkephalins (by rad...

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Bibliographic Details
Main Authors: Daniil eSarkisyan, Muhammad Z. Hussain, Hiroyuki eWatanabe, Olga eKononenko, Igor eBazov, Xing Wu eZhou, Olga eYamskova, Oleg eKrishtal, Victor M. Karpyak, Tatiana eYakovleva, Georgy eBakalkin
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alcoholism
Caudate Nucleus
Putamen
Prodynorphin
proenkephalin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00187/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00187/full

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