Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9

Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9

Genetic approach using rat congenic lines between SHRSP/Izm and WKY/Izm identified stromal interaction molecule 1 (Stim1), an essential component of store-operated Ca2+ entry (SOCE), as a promising candidate gene responsible for the exaggerated sympathetic response to stress in SHRSP. Since SHRSP ha...

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Bibliographic Details
Main Authors: Batbayar Odongoo, Hiroki Ohara, Davis Ngarashi, Takehito Kaneko, Yayoi Kunihiro, Tomoji Mashimo, Toru Nabika
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Clinical and Experimental Hypertension
Subjects:
shrsp
crispr/cas9
stim1
store-operated ca2+ entry (soce)
sympathetic response
stress
Online Access:http://dx.doi.org/10.1080/10641963.2020.1797085

Internet

http://dx.doi.org/10.1080/10641963.2020.1797085

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