IFN-γ is essential for alveolar macrophage–driven pulmonary inflammation in macrophage activation syndrome

IFN-γ is essential for alveolar macrophage–driven pulmonary inflammation in macrophage activation syndrome

Macrophage activation syndrome (MAS) is a life-threatening cytokine storm complicating systemic juvenile idiopathic arthritis (SJIA) driven by IFN-γ. SJIA and MAS are also associated with an unexplained emerging inflammatory lung disease (SJIA-LD), with our recent work supporting pulmonary activatio...

Full description

Bibliographic Details
Main Authors: Denny K. Gao, Nathan Salomonis, Maggie Henderlight, Christopher Woods, Kairavee Thakkar, Alexei A. Grom, Sherry Thornton, Michael B. Jordan, Kathryn A. Wikenheiser-Brokamp, Grant S. Schulert
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-09-01
Series:JCI Insight
Subjects:
Inflammation
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.147593

Internet

https://doi.org/10.1172/jci.insight.147593

Similar Items