Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune signaling pathways. Consequently, viruses have...

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Bibliographic Details
Main Authors: Myriam Scherer, Stefan Klingl, Madhumati Sevvana, Victoria Otto, Eva-Maria Schilling, Joachim D Stump, Regina Müller, Nina Reuter, Heinrich Sticht, Yves A Muller, Thomas Stamminger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1004512

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https://doi.org/10.1371/journal.ppat.1004512

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