Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH

Genetic deletion or pharmacologic inhibition of the Nlrp3 inflammasome did not ameliorate experimental NASH

It has been postulated that inflammasomes, in particular the NLRP3 (NLR family pyrin domain containing 3) inflammasome, mediate the necroinflammation and fibrosis that characterize nonalcoholic steatohepatitis (NASH) by engaging innate immune responses. We aimed to investigate the impact of genetic...

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Bibliographic Details
Main Authors: George N. Ioannou, Christian L. Horn, Vishal Kothari, Matthew M. Yeh, Irene Shyu, Sum P. Lee, Christopher E. Savard
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Journal of Lipid Research
Subjects:
cholesterol
dietary fat
inflammation
lipids
liver
fatty liver,
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523000032

Internet

http://www.sciencedirect.com/science/article/pii/S0022227523000032

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