Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation.

Triptolide induces growth inhibition and apoptosis of human laryngocarcinoma cells by enhancing p53 activities and suppressing E6-mediated p53 degradation.

Triptolide, an active compound extracted from Chinese herb Leigongteng (Tripterygium wilfordii Hook F.), shows a broad-spectrum of anticancer activity through its cytotoxicity. However, the efficacy of triptolide on laryngocarcinoma rarely been evaluated, and the mechanism by which triptolide-induce...

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Bibliographic Details
Main Authors: Fei Zhao, Weiwei Huang, Tamgue Ousman, Bin Zhang, Yangyang Han, Daguia Zambe John Clotaire, Chen Wang, Huanhuan Chang, Huanan Luo, Xiaoyong Ren, Ming Lei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3828261?pdf=render

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http://europepmc.org/articles/PMC3828261?pdf=render

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