The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial

The CHARTER-Ireland trial: can nebulised heparin reduce acute lung injury in patients with SARS-CoV-2 requiring advanced respiratory support in Ireland: a study protocol and statistical analysis plan for a randomised control trial

Abstract Background COVID-19 pneumonia is associated with the development of acute respiratory distress syndrome (ARDS) displaying some typical histological features. These include diffuse alveolar damage with extensive pulmonary coagulation activation. This results in fibrin deposition in the micro...

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Bibliographic Details
Main Authors: John Robert Sheehan, Padraig Calpin, Maeve Kernan, Claire Kelly, Siobhan Casey, Darragh Murphy, Alberto Alvarez-Iglesias, Camilla Giacomini, Catriona Cody, Gerard Curley, Shane McGeary, Ciara Hanley, Bairbre McNicholas, Frank van Haren, John G. Laffey, David Cosgrave
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Trials
Subjects:
COVID-19
CHARTER
Acute respiratory distress syndrome
SARS-CoV-2
Respiratory support
Nebulised heparin
Online Access:https://doi.org/10.1186/s13063-022-06518-z

Internet

https://doi.org/10.1186/s13063-022-06518-z

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