TRH and TRH-like peptide levels covary with caloric restriction and oral metformin in rat heart and testis

TRH and TRH-like peptide levels covary with caloric restriction and oral metformin in rat heart and testis

Background: Obesity, type 2 diabetes, and major depression are common comorbidities in aging populations. Metformin (MF) mimics effects of caloric restriction (CR) which increases health and life spans. CR suppresses central TRH activity resulting in bradycardia and suppression of energy expenditure...

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Bibliographic Details
Main Authors: Albert Eugene Pekary, Albert Sattin
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Endocrine and Metabolic Science
Subjects:
Thyrotropin releasing hormone
Metformin
Caloric restriction
Cardioprotection
Testicular function
Online Access:http://www.sciencedirect.com/science/article/pii/S2666396122000048

Internet

http://www.sciencedirect.com/science/article/pii/S2666396122000048

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