(−)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer

(−)-Epigallocatechin 3-Gallate Synthetic Analogues Inhibit Fatty Acid Synthase and Show Anticancer Activity in Triple Negative Breast Cancer

(−)-Epigallocatechin 3-gallate (EGCG) is a natural polyphenol from green tea with reported anticancer activity and capacity to inhibit the lipogenic enzyme fatty acid synthase (FASN), which is overexpressed in several human carcinomas. To improve the pharmacological profile of EGCG, we previously de...

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Bibliographic Details
Main Authors: Joan Crous-Masó, Sònia Palomeras, Joana Relat, Cristina Camó, Úrsula Martínez-Garza, Marta Planas, Lidia Feliu, Teresa Puig
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
triple-negative breast cancer
fatty acid synthase
FASN inhibition
polyphenolic FASN inhibitors
(−)-epigallocatechin 3-gallate
synthetic analogues
apoptosis
anticancer activity
Online Access:http://www.mdpi.com/1420-3049/23/5/1160

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http://www.mdpi.com/1420-3049/23/5/1160

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