Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS

Bioenergetic abnormalities in discrete cerebral motor pathways presage spinal cord pathology in the G93A SOD1 mouse model of ALS

Multiple cell death pathways are implicated in the etiology of amyotrophic lateral sclerosis (ALS), but the cause of the characteristic motor neuron degeneration remains unknown. To determine whether CNS metabolic defects are critical for ALS pathogenesis, we examined the temporal evolution of energ...

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Bibliographic Details
Main Authors: Susan E. Browne, Lichuan Yang, Jon-Paul DiMauro, Sara W. Fuller, Stephanie C. Licata, M. Flint Beal
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
ATP
Brain
Cerebral glucose metabolism
Corticospinal tract
Creatine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000039

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http://www.sciencedirect.com/science/article/pii/S0969996106000039

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