Model acetylcholinesterase‐Fc fusion glycoprotein biotechnology system for the manufacture of an organophosphorus toxicant bioscavenging countermeasure

Model acetylcholinesterase‐Fc fusion glycoprotein biotechnology system for the manufacture of an organophosphorus toxicant bioscavenging countermeasure

Abstract Organophosphate (OP) toxicants remain an active threat to public health and to warfighters in the military. Current countermeasures require near immediate administration following OP exposure and are reported to have controversial efficacies. Acetylcholinesterase (AChE) fused to the human i...

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Bibliographic Details
Main Authors: Thomas G. Biel, Talia Faison, Alicia M. Matthews, Uriel Ortega‐Rodriguez, Vincent M. Falkowski, Edward Meek, Xin Bush, Matthew Flores, Sarah Johnson, Wells W. Wu, Mari Lehtimaki, Rong‐Fong Shen, Cyrus Agarabi, V. Ashutosh Rao, Janice E. Chambers, Tongzhong Ju
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Bioengineering & Translational Medicine
Subjects:
acetylcholinesterase fusion protein
biomanufacturing
bioscavenger
glycosylation
organophosphorus toxicant
Online Access:https://doi.org/10.1002/btm2.10666

Internet

https://doi.org/10.1002/btm2.10666

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