Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3–c]quinolin-12(12H)-one as potential breast cancer drugs

Structure-based design, synthesis and biological evaluation of N-substituted 6H-thiochromeno[2,3–c]quinolin-12(12H)-one as potential breast cancer drugs

Tetraheterocyclic compounds, derived from natural sources and contemporary pharmaceuticals, have shown promise as multitarget therapeutic agents. However, their mechanisms of action remain partially understood. In this study, we synthesized a series of 6H-thiochromeno[2,3-c]quinolin-12(12H)-one deri...

Full description

Bibliographic Details
Main Authors: Maryam Rachmawati Sumitra, Lung-Ching Chen, Wei-Chen Tsai, Muhamad Ansar, Bashir Lawal, Ntlotlang Mokgautsi, Jih-Hwa Guh, Alexander T.H Wu, Hsu-Shan Huang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Arabian Journal of Chemistry
Subjects:
Breast cancer
NCI 60-cell panel assay
Molecular docking
Tetraheterocyclic
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223008857

Internet

http://www.sciencedirect.com/science/article/pii/S1878535223008857

Similar Items