Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro

Bifunctional Small Molecules Enhance Neutrophil Activities Against Aspergillus fumigatus in vivo and in vitro

Aspergillosis is difficult to treat and carries a high mortality rate in immunocompromised patients. Neutrophils play a critical role in control of infection but may be diminished in number and function during immunosuppressive therapies. Here, we measure the effect of three bifunctional small molec...

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Bibliographic Details
Main Authors: Caroline N. Jones, Felix Ellett, Anne L. Robertson, Kevin M. Forrest, Kevin Judice, James M. Balkovec, Martin Springer, James F. Markmann, Jatin M. Vyas, H. Shaw Warren, Daniel Irimia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
neutrophil
fungi (mycelium and spores)
Aspergillus fumigatus (A. fumigatus)
bifunctional molecules
cloudbreak
microfluidic
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00644/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00644/full

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