Quantification of hematopoietic stem and progenitor cells by targeted DNA methylation analysis

Abstract Hematopoietic stem and progenitor cells (HSPCs) are quantified in daily clinical practice by flow cytometry. In this study, we provide proof of concept that HSPCs can also be estimated by targeted DNA methylation (DNAm) analysis. The DNAm levels at three individual CG dinucleotides (CpG sit...

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Detalhes bibliográficos
Main Authors: Ledio Bocova, Wouter Hubens, Cordula Engel, Steffen Koschmieder, Edgar Jost, Wolfgang Wagner
Formato: Artigo
Idioma:English
Publicado em: BMC 2023-06-01
Colecção:Clinical Epigenetics
Assuntos:
Acesso em linha:https://doi.org/10.1186/s13148-023-01521-w