The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas.

The host-directed therapeutic imatinib mesylate accelerates immune responses to Mycobacterium marinum infection and limits pathology associated with granulomas.

Infections caused by members of the mycobacterium tuberculosis complex [MTC] and nontuberculous mycobacteria [NTM] can induce widespread morbidity and mortality in people. Mycobacterial infections cause both a delayed immune response, which limits rate of bacterial clearance, and formation of granul...

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Bibliographic Details
Main Authors: Tesia L Cleverley, Siri Peddineni, Jeannette Guarner, Francesca Cingolani, Pamela K Garcia, Heather Koehler, Edward S Mocarski, Daniel Kalman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011387

Internet

https://doi.org/10.1371/journal.ppat.1011387

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