Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis

Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis

Although the pathogenesis of pulmonary fibrosis remains unclear, it is known to involve epithelial injury and epithelial-mesenchymal transformation (EMT) as a consequence of cigarette smoke (CS) exposure. Moreover, smoking deposits iron in the mitochondria of alveolar epithelial cells. Iron overload...

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Bibliographic Details
Main Authors: Mai Takahashi, Kenji Mizumura, Yasuhiro Gon, Tetsuo Shimizu, Yutaka Kozu, Sotaro Shikano, Yuko Iida, Mari Hikichi, Shinichi Okamoto, Kota Tsuya, Asami Fukuda, Shiho Yamada, Kaori Soda, Shu Hashimoto, Shuichiro Maruoka
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
iron metabolism
mitochondrial dysfunction
cigarette smoke
reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.643980/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.643980/full

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