Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads

Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads

Onchocerciasis and lymphatic filariasis are neglected tropical diseases caused by infection with filarial worms. Annual or biannual mass drug administration with microfilaricidal drugs that kill the microfilarial stages of the parasites has helped reduce infection rates and thus prevent transmission...

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Bibliographic Details
Main Authors: Emma L. Gunderson, Clifford Bryant, Christina A. Bulman, Chelsea Fischer, Mona Luo, Ian Vogel, Kee-Chong Lim, Shabnam Jawahar, Nancy Tricoche, Denis Voronin, Christopher Corbo, Rene B. Ayiseh, Faustin P. T. Manfo, Glory E. Mbah, Fidelis Cho-Ngwa, Brenda Beerntsen, Adam R. Renslo, Sara Lustigman, Judy A. Sakanari
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceuticals
Subjects:
repurposed drugs
pyrvinium pamoate
filarial diseases
macrofilaricides
Online Access:https://www.mdpi.com/1424-8247/15/2/189

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https://www.mdpi.com/1424-8247/15/2/189

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