Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model
Platelets buoy up cancer metastasis via arresting cancer cells, enhancing their adhesion, and facilitating their extravasation through the vasculature. When deprived of intracellular and granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nano...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383522000181 |
| _version_ | 1811314972209184768 |
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| author | Longlong Zhang Yuefei Zhu Xunbin Wei Xing Chen Yang Li Ying Zhu Jiaxuan Xia Yiheng Huang Yongzhuo Huang Jianxin Wang Zhiqing Pang |
| author_facet | Longlong Zhang Yuefei Zhu Xunbin Wei Xing Chen Yang Li Ying Zhu Jiaxuan Xia Yiheng Huang Yongzhuo Huang Jianxin Wang Zhiqing Pang |
| author_sort | Longlong Zhang |
| collection | DOAJ |
| description | Platelets buoy up cancer metastasis via arresting cancer cells, enhancing their adhesion, and facilitating their extravasation through the vasculature. When deprived of intracellular and granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nanoplatesomes by fusing platelet membranes with lipid membranes (P-Lipo) to restrain metastatic tumor formation more efficiently. It was shown nanoplateletsomes bound with circulating tumor cells (CTC) efficiently, interfered with CTC arrest by vessel endothelial cells, CTC extravasation through endothelial layers, and epithelial-mesenchymal transition of tumor cells as nanodecoys. More importantly, in the mouse breast tumor metastasis model, nanoplateletsomes could decrease CTC survival in the blood and counteract metastatic tumor growth efficiently by inhibiting the inflammation and suppressing CTC escape. Therefore, nanoplatelesomes might usher in a new avenue to suppress lung metastasis. |
| first_indexed | 2024-04-13T11:22:02Z |
| format | Article |
| id | doaj.art-47f1d184fb3b47eb939af8d7ed98770b |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-04-13T11:22:02Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-47f1d184fb3b47eb939af8d7ed98770b2022-12-22T02:48:47ZengElsevierActa Pharmaceutica Sinica B2211-38352022-08-0112834273447Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse modelLonglong Zhang0Yuefei Zhu1Xunbin Wei2Xing Chen3Yang Li4Ying Zhu5Jiaxuan Xia6Yiheng Huang7Yongzhuo Huang8Jianxin Wang9Zhiqing Pang10Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaState Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, ChinaState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, ChinaDepartment of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China; Institute of Materia Medica, Academy of Chinese and Western Integrative Medicine, Fudan University, Shanghai 201203, China; Corresponding authors.Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China; Corresponding authors.Platelets buoy up cancer metastasis via arresting cancer cells, enhancing their adhesion, and facilitating their extravasation through the vasculature. When deprived of intracellular and granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nanoplatesomes by fusing platelet membranes with lipid membranes (P-Lipo) to restrain metastatic tumor formation more efficiently. It was shown nanoplateletsomes bound with circulating tumor cells (CTC) efficiently, interfered with CTC arrest by vessel endothelial cells, CTC extravasation through endothelial layers, and epithelial-mesenchymal transition of tumor cells as nanodecoys. More importantly, in the mouse breast tumor metastasis model, nanoplateletsomes could decrease CTC survival in the blood and counteract metastatic tumor growth efficiently by inhibiting the inflammation and suppressing CTC escape. Therefore, nanoplatelesomes might usher in a new avenue to suppress lung metastasis.http://www.sciencedirect.com/science/article/pii/S2211383522000181NanoplateletsomeBreast cancerTumor metastasisCirculating tumor cellsNanodecoyImmunosuppressive micrometastatic environment |
| spellingShingle | Longlong Zhang Yuefei Zhu Xunbin Wei Xing Chen Yang Li Ying Zhu Jiaxuan Xia Yiheng Huang Yongzhuo Huang Jianxin Wang Zhiqing Pang Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model Acta Pharmaceutica Sinica B Nanoplateletsome Breast cancer Tumor metastasis Circulating tumor cells Nanodecoy Immunosuppressive micrometastatic environment |
| title | Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model |
| title_full | Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model |
| title_fullStr | Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model |
| title_full_unstemmed | Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model |
| title_short | Nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model |
| title_sort | nanoplateletsomes restrain metastatic tumor formation through decoy and active targeting in a preclinical mouse model |
| topic | Nanoplateletsome Breast cancer Tumor metastasis Circulating tumor cells Nanodecoy Immunosuppressive micrometastatic environment |
| url | http://www.sciencedirect.com/science/article/pii/S2211383522000181 |
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