FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

The sorting of RNA molecules to subcellular locations facilitates the activity of spatially restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FMRP for efficient transport to neurites. We found that these transcr...

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Bibliographic Details
Main Authors: Raeann Goering, Laura I Hudish, Bryan B Guzman, Nisha Raj, Gary J Bassell, Holger A Russ, Daniel Dominguez, J Matthew Taliaferro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-06-01
Series:eLife
Subjects:
RNA localization
FMRP
fragile x syndrome
Online Access:https://elifesciences.org/articles/52621

Internet

https://elifesciences.org/articles/52621

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