Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder
Abstract Objectives Vascular endothelial growth factor (VEGF) has been related to the etiology of major depressive disorder (MDD). The findings involving the effects of electroconvulsive therapy (ECT) on the VEGF levels have been conflicting. The aim was to examine the possible changes in the VEGF l...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.2001 |
| _version_ | 1797754646481076224 |
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| author | Annamari Sorri Kaija Järventausta Olli Kampman Kai Lehtimäki Minna Björkqvist Kati Tuohimaa Mari Hämäläinen Eeva Moilanen Esa Leinonen |
| author_facet | Annamari Sorri Kaija Järventausta Olli Kampman Kai Lehtimäki Minna Björkqvist Kati Tuohimaa Mari Hämäläinen Eeva Moilanen Esa Leinonen |
| author_sort | Annamari Sorri |
| collection | DOAJ |
| description | Abstract Objectives Vascular endothelial growth factor (VEGF) has been related to the etiology of major depressive disorder (MDD). The findings involving the effects of electroconvulsive therapy (ECT) on the VEGF levels have been conflicting. The aim was to examine the possible changes in the VEGF levels and their associations with clinical outcome in patients with MDD during ECT. Methods The study comprised 30 patients suffering from MDD. Their plasma VEGF levels were measured at baseline and 2 and 4 hr after the first, fifth, and last ECT session. The severity of depression was quantified by the Montgomery‐Asberg Depression Rating Scale (MADRS). Results The VEGF levels increased between the 2‐hr and 4‐hr measurements during the first (p = .003) and the fifth (p = .017) sessions. The baseline VEGF levels between individual ECT sessions remained unchanged during the ECT series. No correlations were found between the increased VEGF levels and the clinical outcome. Conclusions Electroconvulsive therapy increased the VEGF levels repeatedly at the same time point in two different ECT sessions. These increases had no association with the response to ECT. Consequently, VEGF may act as a mediator in the mechanism of action of ECT. |
| first_indexed | 2024-03-12T17:36:33Z |
| format | Article |
| id | doaj.art-47f248e4a97f4f16b3048633e66e4663 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:36:33Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-47f248e4a97f4f16b3048633e66e46632023-08-04T10:56:25ZengWileyBrain and Behavior2162-32792021-08-01118n/an/a10.1002/brb3.2001Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorderAnnamari Sorri0Kaija Järventausta1Olli Kampman2Kai Lehtimäki3Minna Björkqvist4Kati Tuohimaa5Mari Hämäläinen6Eeva Moilanen7Esa Leinonen8Department of Psychiatry Tampere University Hospital Tampere FinlandDepartment of Psychiatry Tampere University Hospital Tampere FinlandDepartment of Psychiatry Tampere University Hospital Tampere FinlandDepartment of Neurosurgery, Neurology and Rehabilitation Tampere University Hospital Tampere FinlandDepartment of Psychiatry Tampere University Hospital Tampere FinlandDepartment of Psychiatry Tampere University Hospital Tampere FinlandThe Immunopharmacology Research Group Faculty of Medicine and Health Technology Tampere University and Tampere University Hospital Tampere FinlandThe Immunopharmacology Research Group Faculty of Medicine and Health Technology Tampere University and Tampere University Hospital Tampere FinlandDepartment of Psychiatry Tampere University Hospital Tampere FinlandAbstract Objectives Vascular endothelial growth factor (VEGF) has been related to the etiology of major depressive disorder (MDD). The findings involving the effects of electroconvulsive therapy (ECT) on the VEGF levels have been conflicting. The aim was to examine the possible changes in the VEGF levels and their associations with clinical outcome in patients with MDD during ECT. Methods The study comprised 30 patients suffering from MDD. Their plasma VEGF levels were measured at baseline and 2 and 4 hr after the first, fifth, and last ECT session. The severity of depression was quantified by the Montgomery‐Asberg Depression Rating Scale (MADRS). Results The VEGF levels increased between the 2‐hr and 4‐hr measurements during the first (p = .003) and the fifth (p = .017) sessions. The baseline VEGF levels between individual ECT sessions remained unchanged during the ECT series. No correlations were found between the increased VEGF levels and the clinical outcome. Conclusions Electroconvulsive therapy increased the VEGF levels repeatedly at the same time point in two different ECT sessions. These increases had no association with the response to ECT. Consequently, VEGF may act as a mediator in the mechanism of action of ECT.https://doi.org/10.1002/brb3.2001electroconvulsive therapymajor depressive disordervascular endothelial growth factor |
| spellingShingle | Annamari Sorri Kaija Järventausta Olli Kampman Kai Lehtimäki Minna Björkqvist Kati Tuohimaa Mari Hämäläinen Eeva Moilanen Esa Leinonen Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder Brain and Behavior electroconvulsive therapy major depressive disorder vascular endothelial growth factor |
| title | Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder |
| title_full | Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder |
| title_fullStr | Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder |
| title_full_unstemmed | Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder |
| title_short | Electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder |
| title_sort | electroconvulsive therapy increases temporarily plasma vascular endothelial growth factor in patients with major depressive disorder |
| topic | electroconvulsive therapy major depressive disorder vascular endothelial growth factor |
| url | https://doi.org/10.1002/brb3.2001 |
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