Elucidating the role of keratin 75 in enamel using Krt75tm1Der knock-in mouse model

Elucidating the role of keratin 75 in enamel using Krt75tm1Der knock-in mouse model

Keratin 75 (K75) was recently discovered in ameloblasts and enamel organic matrix. Carriers of A161T substitution in K75 present with the skin condition Pseudofollicullitis barbae. This mutation is also associated with high prevalence of caries and compromised structural and mechanical properties of...

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Bibliographic Details
Main Authors: Rutuja Deshmukh, Brent Vasquez, Lasya Bhogadi, Claire M. Gabe, Lyudmila Lukashova, Kostas Verdelis, Maria I. Morasso, Elia Beniash
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Physiology
Subjects:
keratin
ameloblast
enamel matrix
dental caries
biomineralization
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1102553/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1102553/full

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