Elucidating the role of keratin 75 in enamel using Krt75tm1Der knock-in mouse model
Keratin 75 (K75) was recently discovered in ameloblasts and enamel organic matrix. Carriers of A161T substitution in K75 present with the skin condition Pseudofollicullitis barbae. This mutation is also associated with high prevalence of caries and compromised structural and mechanical properties of...
Main Authors: | Rutuja Deshmukh, Brent Vasquez, Lasya Bhogadi, Claire M. Gabe, Lyudmila Lukashova, Kostas Verdelis, Maria I. Morasso, Elia Beniash |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-12-01
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Series: | Frontiers in Physiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1102553/full |
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