Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1

Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1

A hallmark of COVID-19 is a hyperinflammatory state associated with severity. Monocytes undergo metabolic reprogramming and produce inflammatory cytokines when stimulated with SARS-CoV-2. We hypothesized that binding by the viral spike protein mediates this effect, and that drugs which regulate immu...

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Autors principals: Theodore J. Cory, Russell S. Emmons, Johnathan R. Yarbro, Kierstin L. Davis, Brandt D. Pence
Format: Article
Idioma:English
Publicat: Frontiers Media S.A. 2021-11-01
Col·lecció:Frontiers in Immunology
Matèries:
COVID-19
SARS-CoV-2
immunometabolism
inflammation
monocyte
Accés en línia:https://www.frontiersin.org/articles/10.3389/fimmu.2021.733921/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.733921/full

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