A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules

A local-optimization refinement algorithm in single particle analysis for macromolecular complex with multiple rigid modules

ABSTRACT Single particle analysis, which can be regarded as an average of signals from thousands or even millions of particle projections, is an efficient method to study the three-dimensional structures of biological macromolecules. An intrinsic assumption in single particle analysis is that all th...

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Bibliographic Details
Main Authors: Hong Shan, Zihao Wang, Fa Zhang, Yong Xiong, Chang-Cheng Yin, Fei Sun
Format: Article
Language:English
Published: Oxford University Press 2015-12-01
Series:Protein & Cell
Subjects:
cryo-electron microscopy
single particle analysis
conformational heterogeneity
rigid module
local optimization refinement
Online Access:http://link.springer.com/article/10.1007/s13238-015-0229-2

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http://link.springer.com/article/10.1007/s13238-015-0229-2

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