Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application

Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application

IntroductionSarcomas are rare heterogeneous malignant tumors that originate and develop in soft tissue or bone. Effective treatment for sarcomas is still limited to traditional chemotherapy and surgery that are often ineffective for recurrent disease. Cyclin-dependent kinases (CDKs) promote abnormal...

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Bibliographic Details
Main Authors: Takashi Higuchi, Kentaro Igarashi, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Michael Bouvet, Hiroyuki Tsuchiya, Robert M. Hoffman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
patient-derived orthotopic xenograft (PDOX)
sarcoma
CDK4/6 inhibitor
palbociblib
osteosarcoma
soft-tissue sarcoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.957844/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.957844/full

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