The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population

The chromatin and single-cell transcriptional landscapes of CD4 T cells in inflammatory bowel disease link risk loci with a proinflammatory Th17 cell population

IntroductionThe imbalance between Th17 and regulatory T cells in inflammatory bowel diseases (IBD) promotes intestinal epithelial cell damage. In this scenario, T helper cell lineage commitment is accompanied by dynamic changes to the chromatin that facilitate or repress gene expression. MethodsHere...

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Bibliographic Details
Main Authors: Tiago S. Medina, Alex Murison, Michelle Smith, Gabriela S. Kinker, Ankur Chakravarthy, Glauco A. F. Vitiello, Williams Turpin, Shu Yi Shen, Helen L. Yau, Olga F. Sarmento, William Faubion, Mathieu Lupien, Mark S. Silverberg, Cheryl H. Arrowsmith, Daniel D. De Carvalho
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease (IBD)
CD4 T cells
genetic variants
pathogenic (p)Th17 cells
cytotoxicity
Crohn's disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161901/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1161901/full

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