Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma

Epigenome-Wide Association Studies of the Fractional Exhaled Nitric Oxide and Bronchodilator Drug Response in Moderate-to-Severe Pediatric Asthma

Asthma is the most prevalent pediatric chronic disease. Bronchodilator drug response (BDR) and fractional exhaled nitric oxide (FeNO) are clinical biomarkers of asthma. Although DNA methylation (DNAm) contributes to asthma pathogenesis, the influence of DNAm on BDR and FeNO is scarcely investigated....

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Bibliographic Details
Main Authors: Mario Martin-Almeida, Javier Perez-Garcia, Esther Herrera-Luis, Carlos Rosa-Baez, Mario Gorenjak, Anne H. Neerincx, Olaia Sardón-Prado, Antoaneta A. Toncheva, Susanne Harner, Christine Wolff, Susanne Brandstetter, Elisa Valletta, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Vojko Berce, Paula Corcuera-Elosegui, Javier Korta-Murua, Heike Buntrock-Döpke, Susanne J. H. Vijverberg, Joris C. Verster, Nikki Kerssemakers, Anna M Hedman, Catarina Almqvist, Jesús Villar, Aletta D. Kraneveld, Uroš Potočnik, Michael Kabesch, Anke H. Maitland-van der Zee, Maria Pino-Yanes, on behalf of the SysPharmPediA Consortium
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Biomedicines
Subjects:
epigenetic
biomarker
methylation
asthma
FeNO
BDR
Online Access:https://www.mdpi.com/2227-9059/11/3/676

Internet

https://www.mdpi.com/2227-9059/11/3/676

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