BCI-215, a Dual-Specificity Phosphatase Inhibitor, Reduces UVB-Induced Pigmentation in Human Skin by Activating Mitogen-Activated Protein Kinase Pathways

BCI-215, a Dual-Specificity Phosphatase Inhibitor, Reduces UVB-Induced Pigmentation in Human Skin by Activating Mitogen-Activated Protein Kinase Pathways

Background: The dysregulation of melanin production causes skin-disfiguring ultraviolet (UV)-associated hyperpigmented spots. Previously, we found that the activation of c-Jun N-terminal kinase (JNK), a mitogen-activated protein kinase (MAPK), inhibited melanogenesis. Methods: We selected BCI-215 as...

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Bibliographic Details
Main Authors: Jeong Hyeon Lee, Myoung Eun Choi, Hongchan An, Ju Won Moon, Hye Jin Yeo, Youngsup Song, Sung Eun Chang
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Molecules
Subjects:
BCI-215
dual-specificity phosphatase
melanogenesis
mitogen-activated protein kinase
ultraviolet radiation
Online Access:https://www.mdpi.com/1420-3049/27/17/5449

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https://www.mdpi.com/1420-3049/27/17/5449

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