Cuprizone-induced Demyelination in Mouse Brain is not due to Depletion of Copper
The cuprizone (CPZ) model allows the study of the biochemical processes underlying nonautoimmune-mediated demyelination, remyelination, and chronic white matter disease progression. CPZ is a copper (Cu) chelator that chiefly causes oligodendrocyte apoptosis in the corpus callosum and cerebellum when...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis
2022-09-01
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| Series: | ASN Neuro |
| Online Access: | https://doi.org/10.1177/17590914221126367 |