Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate

Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate

Virulence gene expression in the human pathogen, S. aureus is regulated by the agr (accessory gene regulator) quorum sensing (QS) system which is conserved in diverse Gram-positive bacteria. The agr QS signal molecule is an autoinducing peptide (AIP) generated via the initial processing of the AgrD...

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Bibliographic Details
Main Authors: Philip Bardelang, Ewan J. Murray, Isobel Blower, Sara Zandomeneghi, Alice Goode, Rohanah Hussain, Divya Kumari, Giuliano Siligardi, Katsuaki Inoue, Jeni Luckett, James Doutch, Jonas Emsley, Weng C. Chan, Philip Hill, Paul Williams, Boyan B. Bonev
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Chemistry
Subjects:
quorum sensing
AgrB
AgrD
Staphylococcus aureus
membrane protein structure
molecular dynamics simulations
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1113885/full

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https://www.frontiersin.org/articles/10.3389/fchem.2023.1113885/full

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