p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells

p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells

P43 is a truncated form of thyroid hormone receptor α localized in mitochondria, which stimulates mitochondrial respiratory chain activity. Previously, we showed that deletion of p43 led to reduction of pancreatic islet density and a loss of glucose-stimulated insulin secretion in adult mice. The pr...

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Bibliographic Details
Main Authors: Emilie Blanchet, Laurence Pessemesse, Christine Feillet-Coudray, Charles Coudray, Chantal Cabello, Christelle Bertrand-Gaday, François Casas
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
thyroid hormone
p43
mitochondria
beta-cells
insulin
MafA
Online Access:https://www.mdpi.com/1422-0067/22/5/2489

Internet

https://www.mdpi.com/1422-0067/22/5/2489

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