Mapping the glial transcriptome in Huntington’s disease using snRNAseq: selective disruption of glial signatures across brain regions

Mapping the glial transcriptome in Huntington’s disease using snRNAseq: selective disruption of glial signatures across brain regions

Abstract Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease with a fatal outcome. There is accumulating evidence of a prominent role of glia in the pathology of HD, and we investigated this by conducting single nuclear RNA sequencing (snRNAseq) of human post mortem brain in...

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Bibliographic Details
Main Authors: Sunniva M. K. Bøstrand, Luise A. Seeker, Nadine Bestard-Cuche, Nina-Lydia Kazakou, Sarah Jäkel, Boyd Kenkhuis, Neil C. Henderson, Susanne T. de Bot, Willeke M. C. van Roon-Mom, Josef Priller, Anna Williams
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Acta Neuropathologica Communications
Subjects:
Huntington’s disease
Transcriptomics
Glia
Chaperones
Online Access:https://doi.org/10.1186/s40478-024-01871-3

Internet

https://doi.org/10.1186/s40478-024-01871-3

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