Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease

Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease

Decreased activity of cAMP responsive element-binding protein (CREB) is thought to contribute to the death of striatal medium spiny neurons in Huntington's disease (HD). Therefore, therapies that increase levels of activated CREB, may be effective in fighting neurodegeneration in HD. In this st...

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Bibliographic Details
Main Authors: Carmela Giampà, Stefano Patassini, Antonella Borreca, Daunia Laurenti, Fabrizia Marullo, Giorgio Bernardi, Frank S. Menniti, Francesca R. Fusco
Format: Article
Language:English
Published: Elsevier 2009-06-01
Series:Neurobiology of Disease
Subjects:
PDE inhibitors
Rat
Huntington's disease
Striatum
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000448

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109000448

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