The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks
Interferon-γ (IFN-γ), an inflammatory biomarker that promotes antiviral immunity, may be a prerequisite for sociability. IFN-γ production in older adulthood is driven by late-differentiated CD8+ T cells, particularly CD28−and CD57+ subsets, which increase with age, reduce immune response, and increa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622001028 |
| _version_ | 1797998037905178624 |
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| author | Elana M. Gloger Stephanie T. Judge Rebecca G. Reed Steven R. Presnell Ahmad Al-Attar Charles T. Lutz Suzanne C. Segerstrom |
| author_facet | Elana M. Gloger Stephanie T. Judge Rebecca G. Reed Steven R. Presnell Ahmad Al-Attar Charles T. Lutz Suzanne C. Segerstrom |
| author_sort | Elana M. Gloger |
| collection | DOAJ |
| description | Interferon-γ (IFN-γ), an inflammatory biomarker that promotes antiviral immunity, may be a prerequisite for sociability. IFN-γ production in older adulthood is driven by late-differentiated CD8+ T cells, particularly CD28−and CD57+ subsets, which increase with age, reduce immune response, and increase chronic disease risk. The present study investigated the relationship between late-differentiated T cells (LDTC) and sociability in a longitudinal study of healthy aging. 139 older adults (Mage = 77.95, range 65–93; 58% female, 57% college educated, and 94% Caucasian) provided data at up to 10 occasions (M = 7). Social network size and diversity and cytomegalovirus (CMV) status were collected at every wave. Percentage of LDTC was measured at up to 4 waves and averaged for each participant. There were no significant main effects of LDTC or interactions between LDTC and time on social network size or diversity. Adjustment for baseline age, gender, and sensitivity analyses including CMV and imputed data did not change results. IFN-γ may not play a role in dictating social behavior in older adults. Alternately, LDTC may not have accurately represented circulating levels of IFN-γ. Future work should continue exploring IFN-γ and social behavior, particularly as it relates to age-related changes.The role of IFN-γ-producing, late-differentiated T cells in older adults’ social networks. |
| first_indexed | 2024-04-11T10:42:08Z |
| format | Article |
| id | doaj.art-481bfeb45b854fcbb39c396461a65e76 |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-04-11T10:42:08Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-481bfeb45b854fcbb39c396461a65e762022-12-22T04:29:09ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-11-0125100512The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networksElana M. Gloger0Stephanie T. Judge1Rebecca G. Reed2Steven R. Presnell3Ahmad Al-Attar4Charles T. Lutz5Suzanne C. Segerstrom6Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, United States; Corresponding author. Department of Psychology, The University of Kentucky, 125 Kastle Hall, Lexington, KY, 40506, United States.Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, United StatesDepartment of Psychology, Kenneth P. Dietrich School of Arts and Sciences, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Pathology and Laboratory Medicine, College of Medicine, University of Kentucky, Lexington, KY, United StatesDepartment of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, KY, United StatesInterferon-γ (IFN-γ), an inflammatory biomarker that promotes antiviral immunity, may be a prerequisite for sociability. IFN-γ production in older adulthood is driven by late-differentiated CD8+ T cells, particularly CD28−and CD57+ subsets, which increase with age, reduce immune response, and increase chronic disease risk. The present study investigated the relationship between late-differentiated T cells (LDTC) and sociability in a longitudinal study of healthy aging. 139 older adults (Mage = 77.95, range 65–93; 58% female, 57% college educated, and 94% Caucasian) provided data at up to 10 occasions (M = 7). Social network size and diversity and cytomegalovirus (CMV) status were collected at every wave. Percentage of LDTC was measured at up to 4 waves and averaged for each participant. There were no significant main effects of LDTC or interactions between LDTC and time on social network size or diversity. Adjustment for baseline age, gender, and sensitivity analyses including CMV and imputed data did not change results. IFN-γ may not play a role in dictating social behavior in older adults. Alternately, LDTC may not have accurately represented circulating levels of IFN-γ. Future work should continue exploring IFN-γ and social behavior, particularly as it relates to age-related changes.The role of IFN-γ-producing, late-differentiated T cells in older adults’ social networks.http://www.sciencedirect.com/science/article/pii/S2666354622001028 |
| spellingShingle | Elana M. Gloger Stephanie T. Judge Rebecca G. Reed Steven R. Presnell Ahmad Al-Attar Charles T. Lutz Suzanne C. Segerstrom The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks Brain, Behavior, & Immunity - Health |
| title | The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks |
| title_full | The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks |
| title_fullStr | The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks |
| title_full_unstemmed | The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks |
| title_short | The role of late-differentiated T cells, a proxy for IFN-γ-production, in older adults’ social networks |
| title_sort | role of late differentiated t cells a proxy for ifn γ production in older adults social networks |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622001028 |
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