Significant Roles of Notch <i>O</i>-Glycosylation in Cancer
Notch signaling, which was initially identified in <i>Drosophila</i> wing morphogenesis, plays pivotal roles in cell development and differentiation. Optimal Notch pathway activity is essential for normal development and dysregulation of Notch signaling leads to various human diseases, i...
Main Authors: | Weiwei Wang, Tetsuya Okajima, Hideyuki Takeuchi |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-03-01
|
Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/6/1783 |
Similar Items
-
Current Views on the Roles of <i>O</i>-Glycosylation in Controlling Notch-Ligand Interactions
by: Wataru Saiki, et al.
Published: (2021-02-01) -
Modulation of the NOTCH1 Pathway by LUNATIC FRINGE Is Dominant over That of MANIC or RADICAL FRINGE
by: Florian Pennarubia, et al.
Published: (2021-09-01) -
Xylosyl Extension of <i>O</i>-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking
by: Yusuke Urata, et al.
Published: (2020-05-01) -
Progress to Clarify How <i>NOTCH3</i> Mutations Lead to CADASIL, a Hereditary Cerebral Small Vessel Disease
by: Ikuko Mizuta, et al.
Published: (2024-01-01) -
Elucidating the Implications of Norovirus <i>N</i>- and <i>O</i>-Glycosylation, <i>O</i>-GlcNAcylation, and Phosphorylation
by: Chia-Chi Cheng, et al.
Published: (2023-03-01)