Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus

Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus

In the past, curcumin was the go-to medication for diabetes, but recent studies have shown that tetrahydrocurcumin is more effective. The problem is that it's not very soluble in water or very bioavailable. So, our research aims to increase the bioavailability and anti-diabetic efficacy of tetr...

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Bibliographic Details
Main Authors: Jai Bharti Sharma, Shailendra Bhatt, Abhishek Tiwari, Varsha Tiwari, Manish Kumar, Ravinder Verma, Deepak Kaushik, Tarun Virmani, Girish Kumar, Omkulthom Al kamaly, Asmaa Saleh, Mohammed Khalid Parvez, Abdulsalam Alhalmi
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Saudi Pharmaceutical Journal
Subjects:
Tetrahydrocurcumin
Box-Behnken design
SLN
Pharmacokinetic study
Pharmacodynamic study
STZ-induced Diabetes Mellitus
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423002220

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http://www.sciencedirect.com/science/article/pii/S1319016423002220

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