Generation of orthotopic patient-derived xenograft models for pancreatic cancer using tumor slices

Summary: Orthotopic patient-derived xenograft models recapitulate the genomic complexity of the original tumor and some aspects of local microenvironment, useful for rapid development and validation of personalized treatment strategies. Here, we precisely describe a protocol for generating tumor sli...

Full description

Bibliographic Details
Main Authors: Alvaro Curiel-Garcia, Amanda R. Decker-Farrell, Stephen A. Sastra, Kenneth P. Olive
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166722007791