Implementing the time-to-event continual reassessment method in the presence of partial orders in a phase I head and neck cancer trial

Implementing the time-to-event continual reassessment method in the presence of partial orders in a phase I head and neck cancer trial

Abstract Background In this article we describe the methodology of the time-to-event continual reassessment method in the presence of partial orders (PO-TITE-CRM) and the process of implementing this trial design into a phase I trial in head and neck cancer called ADePT-DDR. The ADePT-DDR trial aims...

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Bibliographic Details
Main Authors: Amit Patel, Kristian Brock, Daniel Slade, Claire Gaunt, Anthony Kong, Hisham Mehanna, Lucinda Billingham, Piers Gaunt
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Medical Research Methodology
Subjects:
PO-TITE-CRM
ADePT-DDR
Toxicity
Dose-finding
Partial orders
Monotonicity assumption
Online Access:https://doi.org/10.1186/s12874-024-02142-4

Internet

https://doi.org/10.1186/s12874-024-02142-4

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