Differentially Methylated Ultra-Conserved Regions Uc160 and Uc283 in Adenomas and Adenocarcinomas Are Associated with Overall Survival of Colorectal Cancer Patients

Differentially Methylated Ultra-Conserved Regions Uc160 and Uc283 in Adenomas and Adenocarcinomas Are Associated with Overall Survival of Colorectal Cancer Patients

Deregulation of the transcribed ultra-conserved regions (T-UCRs) Uc160, Uc283, and Uc346 has been reported in colorectal cancer (CRC) recently. Here, we investigated promoter methylation of these T-UCRs during the adenoma–carcinoma sequence and their clinical significance in CRC patients. Methylatio...

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Bibliographic Details
Main Authors: Anastasia E. Kottorou, Foteinos-Ioannis D. Dimitrakopoulos, Anna G. Antonacopoulou, Georgia Diamantopoulou, Dimitrios Tsoumas, Angelos Koutras, Thomas Makatsoris, Michalis Stavropoulos, Konstantinos C. Thomopoulos, Alicia Hulbert, Vassiliki Tzelepi, Haralabos P. Kalofonos
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
transcribed-ultra conserved regions
colorectal cancer
adenomas
methylation
prognostic biomarkers
Online Access:https://www.mdpi.com/2072-6694/12/4/895

Internet

https://www.mdpi.com/2072-6694/12/4/895

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