Early Effects of Aβ Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons

Early Effects of Aβ Oligomers on Dendritic Spine Dynamics and Arborization in Hippocampal Neurons

Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to impaired memory and cognitive deficits. Spine loss as well as changes in spine morphology correlates with cognitive impairment in this neurological disorder. Many studies in animal models and ex vivo cultures indicate that amyloi...

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Bibliographic Details
Main Authors: Carolina Ortiz-Sanz, Adhara Gaminde-Blasco, Jorge Valero, Lidia Bakota, Roland Brandt, José L. Zugaza, Carlos Matute, Elena Alberdi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Synaptic Neuroscience
Subjects:
Aβ oligomers
spines
dendrites
Alzheimer’s disease
integrin β1
CaMKII
Online Access:https://www.frontiersin.org/article/10.3389/fnsyn.2020.00002/full

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https://www.frontiersin.org/article/10.3389/fnsyn.2020.00002/full

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