mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated ubiquitination of eIF4A1 in cancer cells

Enhanced protein synthesis is a crucial molecular mechanism that allows cancer cells to survive, proliferate, metastasize, and develop resistance to anti-cancer treatments, and often arises as a consequence of increased signaling flux channeled to mRNA-bearing eukaryotic initiation factor 4F (eIF4F)...

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Bibliographic Details
Main Authors: Dongyue Jiao, Huiru Sun, Xiaying Zhao, Yingji Chen, Zeheng Lv, Qing Shi, Yao Li, Chenji Wang, Kun Gao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-05-01
Series:eLife
Subjects:
tumorigenesis
ubiquitination
phosphorylation
mTORC1/S6K1 signaling
translation
Online Access:https://elifesciences.org/articles/92236

Internet

https://elifesciences.org/articles/92236

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