CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in <i>KMT2A</i>-Rearranged Acute Lymphoblastic Leukemia

CRISPR-Cas9 Library Screening Identifies Novel Molecular Vulnerabilities in <i>KMT2A</i>-Rearranged Acute Lymphoblastic Leukemia

In acute lymphoblastic leukemia (ALL), chromosomal translocations involving the <i>KMT2A</i> gene represent highly unfavorable prognostic factors and most commonly occur in patients less than 1 year of age. Rearrangements of the <i>KMT2A</i> gene drive epigenetic changes that...

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Bibliographic Details
Main Authors: Pauline Schneider, Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Dedeke Rockx-Brouwer, Fabienne R. S. Adriaanse, Veerle Hoeve, Irene Paassen, Jarno Drost, Rob Pieters, Ronald W. Stam
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
<i>KMT2A</i>-rearranged
infant
leukemia
CRISPR-Cas9
epigenome
kinome
Online Access:https://www.mdpi.com/1422-0067/24/17/13207

Internet

https://www.mdpi.com/1422-0067/24/17/13207

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