DNA replication origins retain mobile licensing proteins

DNA replication origins retain mobile licensing proteins

Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase...

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Bibliographic Details
Main Authors: Humberto Sánchez, Kaley McCluskey, Theo van Laar, Edo van Veen, Filip M. Asscher, Belén Solano, John F. X. Diffley, Nynke H. Dekker
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22216-x

Internet

https://doi.org/10.1038/s41467-021-22216-x

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