DNA replication origins retain mobile licensing proteins
Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22216-x |
| _version_ | 1818978444022644736 |
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| author | Humberto Sánchez Kaley McCluskey Theo van Laar Edo van Veen Filip M. Asscher Belén Solano John F. X. Diffley Nynke H. Dekker |
| author_facet | Humberto Sánchez Kaley McCluskey Theo van Laar Edo van Veen Filip M. Asscher Belén Solano John F. X. Diffley Nynke H. Dekker |
| author_sort | Humberto Sánchez |
| collection | DOAJ |
| description | Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase onto DNA. |
| first_indexed | 2024-12-20T16:43:44Z |
| format | Article |
| id | doaj.art-48341162ccdd441d85b494952e9dc0d4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:43:44Z |
| publishDate | 2021-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-48341162ccdd441d85b494952e9dc0d42022-12-21T19:32:59ZengNature PortfolioNature Communications2041-17232021-03-0112111210.1038/s41467-021-22216-xDNA replication origins retain mobile licensing proteinsHumberto Sánchez0Kaley McCluskey1Theo van Laar2Edo van Veen3Filip M. Asscher4Belén Solano5John F. X. Diffley6Nynke H. Dekker7Department of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyChromosome Replication Laboratory, Francis Crick InstituteDepartment of Bionanoscience, Kavli Institute of Nanoscience, Delft University of TechnologyEukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates that lead up to the loading of an MCM helicase onto DNA.https://doi.org/10.1038/s41467-021-22216-x |
| spellingShingle | Humberto Sánchez Kaley McCluskey Theo van Laar Edo van Veen Filip M. Asscher Belén Solano John F. X. Diffley Nynke H. Dekker DNA replication origins retain mobile licensing proteins Nature Communications |
| title | DNA replication origins retain mobile licensing proteins |
| title_full | DNA replication origins retain mobile licensing proteins |
| title_fullStr | DNA replication origins retain mobile licensing proteins |
| title_full_unstemmed | DNA replication origins retain mobile licensing proteins |
| title_short | DNA replication origins retain mobile licensing proteins |
| title_sort | dna replication origins retain mobile licensing proteins |
| url | https://doi.org/10.1038/s41467-021-22216-x |
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