Methadone Blockade of Cardiac Inward Rectifier K+ Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study

Methadone Blockade of Cardiac Inward Rectifier K+ Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study

Background Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K+ current (IKr), the principal mechanism of drug‐associated arrhythmia. Congenital defects of inward rectifier K+ current (IK1) have be...

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Bibliographic Details
Main Authors: Michael G. Klein, Mori J. Krantz, Naheed Fatima, Ashlie Watters, Dayan Colon‐Sanchez, Robert M. Geiger, Robert E. Goldstein, Soroosh Solhjoo, Philip S. Mehler, Thomas P. Flagg, Mark C. Haigney
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
I K1
I Kr
methadone
U waves
ventricular arrhythmia
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.023482

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.121.023482

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