LPS-induced inflammation reduces GABAergic interneuron markers and brain-derived neurotrophic factor in mouse prefrontal cortex and hippocampus

LPS-induced inflammation reduces GABAergic interneuron markers and brain-derived neurotrophic factor in mouse prefrontal cortex and hippocampus

Inflammation, reduced gamma-aminobutyric acidergic (GABAergic) function and altered neuroplasticity are co-occurring pathophysiologies in major depressive disorder (MDD). However, the link between these biological changes remains unclear. We hypothesized that inflammation induces deficits in GABAerg...

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Bibliographic Details
Main Authors: Sara Rezaei, Thomas D. Prévot, Erica Vieira, Etienne Sibille
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Gamma-aminobutyric acid
Major depressive disorder
Lipopolysaccharide
Interneuron
Inflammation
Prefrontal cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354624000395

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http://www.sciencedirect.com/science/article/pii/S2666354624000395

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