Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Open Questions

Tumor Mutational Burden as a Potential Biomarker for Immunotherapy in Pancreatic Cancer: Systematic Review and Still-Open Questions

Tumor mutational burden (TMB) is a numeric index that expresses the number of mutations per megabase (muts/Mb) harbored by tumor cells in a neoplasm. TMB can be determined using different approaches based on next-generation sequencing. In the case of high values, it indicates a potential response to...

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Bibliographic Details
Main Authors: Rita T. Lawlor, Paola Mattiolo, Andrea Mafficini, Seung-Mo Hong, Maria L. Piredda, Sergio V. Taormina, Giuseppe Malleo, Giovanni Marchegiani, Antonio Pea, Roberto Salvia, Valentyna Kryklyva, Jae Il Shin, Lodewijk A. Brosens, Michele Milella, Aldo Scarpa, Claudio Luchini
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
tumor mutation burden
TMB
TML
PD-1
PD-L1
pancreatic cancer
Online Access:https://www.mdpi.com/2072-6694/13/13/3119

Internet

https://www.mdpi.com/2072-6694/13/13/3119

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